A Step-By-Step Synthesis of S-Methylene Linker Containing Triazole-Benzoxazole Hybrids by Click Chemistry Approach: Anticancer Activity in Human Cells

Novel series of triazole-benzoxazole hybrid compounds (7a-7i) have been synthesized via click chemistry between different azide derivatives and benzoxazole terminal alkynes bearing an S-methylene linkage. The starting alkyne was prepared base-catalyzed S-alkylation substrate in two-step procedures. All the intermediates final products were fully characterized by 1D NMR, IR, mass spectrometry, elemental analysis techniques. reported hybrids two heterocyclic rings, i.e., 1,2,3-triazole a single structure, screened for their anticancer activity against nine basic cancer panels as well NCI-60 cell-line. In vitro studies revealed that 7b, 7c, 7d, 7i, 7g showed potent Leukemia, non-small cell lung cancer, renal melanoma cell-lines with GI50 range from 5.61 to 20.87 µM. fraction’s anti-microbial found targeted scaffolds not any significant potency strains.